Potassium teter-butoxide Strikes Again!

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C–H carboxylation of heteroarenes with ambient CO₂

Sabine Fenner^a and   Lutz Ackermann*^a  

Green Chem., 2016, Advance Article

The C–H carboxylation of heteroarenes was achieved under transition metal-free reaction conditions with naturally abundant CO₂ as the C1 source at relatively low temperature. The C–H carboxylation was mediated by KOt-Bu at atmospheric pressure of CO₂, and thereby provided atom- and step-economical access to various heteroaromatic carboxylic acid derivatives.