The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B.; Pieber, B.; Gilmore, K.; Seeberger, P. H.
Max-Planck Institute of Colloids and Interfaces, Potsdam, Germany
Chem. Rev. ASAP
http://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.7b00183
Abstract:
Flow chemistry involves the use of channels or tubing to conduct a
reaction in a continuous stream rather than in a flask. Flow equipment provides chemists
with unique control over reaction parameters enhancing reactivity or in some cases
enabling new reactions. This relatively young technology has received a remarkable
amount of attention in the past decade with many reports on what can be done in flow.
Until recently, however, the question, “Should we do this in flow?” has merely been an
afterthought. This review introduces readers to the basic principles and fundamentals of
flow chemistry and critically discusses recent flow chemistry accounts.
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