Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst

http://pubs.rsc.org/en/Content/ArticleLanding/2016/SC/C5SC03704B?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FSC+%28RSC+-+Chem.+Sci.+latest+articles%29#!divAbstract


Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
Xinyu Cao,ab Sheng-Chun Sha,b Minyan Li,b Byeong-Seon Kim,b Catherine Morgan,b Rudan Huang,a Xiaodong Yangc and Patrick J. Walsh*b

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Chem. Sci., 2016, Advance Article
DOI: 10.1039/C5SC03704B
Received 30 Sep 2015, Accepted 07 Oct 2015
First published online 26 Oct 2015





Nickel(0)-catalyzed cross-coupling of heteroaryl-containing diarylmethanes with both aryl bromides and chlorides has been achieved. The success of this reaction relies on the introduction of a unique nickel/NIXANTPHOS-based catalyst system, which provides a direct route to triarylmethanes from heteroaryl-containing diarylmethanes. Reactivity studies indicate the Ni(NIXANTPHOS)-based catalyst exhibits enhanced reactivity over XANTPHOS derivatives and other Ni(phosphine)-based catalysts in the reactions examined.