From proton transferred to cyclometalated platinum(IV) complex: Crystal structure and biological activity

http://www.sciencedirect.com/science/article/pii/S0022328X1530125X

• Anita Abedi^a, 
• Vahid Amani^b, 
• Nasser Safari^b,, 
• S. Nasser Ostad^c, 
• Behrouz Notash^b

• ^a Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran 19585-936, Iran
• ^b Department of Chemistry, Shahid Beheshti University, G. C., Evin, Tehran 19839-63113, Iran
• ^c Department of Toxicology & Pharmacology, University of Tehran Medical Sciences, Tehran 14155-6451, Iran
• doi:10.1016/j.jorganchem.2015.08.023
• JOMC 2015, 800, 30-37
• 
  
• Abstract: 
A new proton transfer complex of [6,6′-dmbipy.H]₂[PtCl₆] (1) was prepared from the reaction of H₂PtCl₆.6H₂O with 6,6′-dimethyl-2,2'-bipyridine (6,6′-dmbipy) in CH₃CN at room temperature. The cyclometalated complex of mer-[Pt(6,6′-dmbipy-κ²N,C)Cl₃(DMF-κO)] (2) was prepared from the recrystallization of complex 1, in a mixture of DMF/DMSO/H₂O (6:2:1) at 60 °C, in which the first C–H bond activation in a bipyridine ring with Pt(IV) ion was observed. In vitro cytotoxicity against four cultures: NIH-3T3, Caco-2, HT-29 and T47D were studied using MTT assays. Interestingly, compound 2 is more potent in killing a colon cancer cell line than cisplatin, since it exhibits extensively less toxicity on normal cells. Both complexes were characterized by elemental analysis, FT-IR, ¹H NMR, UV–Vis spectra and X-ray crystallography.